The differences between the branded and generic medicines using solid dosage forms: In-vitro dissolution testing.

ABSTRACT:

Introduction

Dissolution is the amount of substance that goes into solution per unit time under standardised conditions of liquid/solid interface, solvent composition and temperature. Dissolution is one of the most important tools to predict the in-vivo bioavailability and in some cases to determine bioequivalence and assure interchangeability.

Aim

To compare the differences in dissolution behaviour of solid dosage forms between innovators (reference products) and their generic counterparts (tested products).

Methods

Four replicates for each batch of 37 tested medicines was carried out using A PT-DT70 dissolution tester from Pharma Test. A total of 13 branded medicines and 24 generic counterparts were obtained locally and internationally to detect any differences in t

SUBMITTER: Al Ameri MN 

PROVIDER: S-EPMC4167181 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature