Automated versus manual hippocampal segmentation in preoperative and postoperative patients with epilepsy.

ABSTRACT:

Objective

To compare manual and automated preoperative and postoperative hippocampal volume measurements in patients with intractable epilepsy.

Methods

We studied 34 patients referred to the Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH) for evaluation of intractable epilepsy and 21 normal volunteers who received 1.5 or 3 T GE Signa magnetic resonance imaging (MRI) scans. Hippocampal volumes were traced manually on each slice and assembled into three-dimensional volumes by investigators who were blinded to other data. Automated volumetric measurements were obtained using FreeSurfer. Statistical analysis was performed with GraphPad Prism.

Results

Automated hippocampal volumes were larger t

SUBMITTER: Germeyan SC 

PROVIDER: S-EPMC4167188 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature