Contralateral interictal spikes are related to tapetum damage in left temporal lobe epilepsy.

ABSTRACT:

Objective

In temporal lobe epilepsy (TLE), the epileptogenic focus is focal and unilateral in the majority of patients. A key characteristic of focal TLE is the presence of subclinical epileptiform activity in both the ictal and contralateral "healthy" hemisphere. Such interictal activity is clinically important, as it may reflect the spread of pathology, potentially leading to secondary epileptogenesis. The role played by white matter pathways in this process is unknown.

Methods

We compared three interhemispheric white matter tracts (anterior commissure, fornix, and tapetum) to determine the pathway most associated with the presence of contralateral interictal spikes. Forty patients with unilateral left or right TLE were categorized based on the presence or absence of contr

SUBMITTER: Pustina D 

PROVIDER: S-EPMC4167250 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature