MiR-107 and miR-99a-3p predict chemotherapy response in patients with advanced colorectal cancer.

ABSTRACT:

Background

MicroRNAs (miRNAs) are involved in numerous biological and pathological processes including colorectal cancer (CRC). The aim of our study was to evaluate the ability of miRNA expression patterns to predict chemotherapy response in a cohort of 78 patients with metastatic CRC (mCRC).

Methods

We examined expression levels of 667 miRNAs in the training cohort and evaluated their potential association with relevant clinical endpoints. We identified a miRNA profile that was analysed by RT-qPCR in an independent cohort. For a set of selected miRNAs, bioinformatic target predictions and pathway analysis were also performed.

Results

Eight miRNAs (let-7 g*, miR-107, miR-299-5p, miR-337-5p, miR-370, miR-505*, miR-889 and miR-99a-3p) were significant predictors of resp

SUBMITTER: Molina-Pinelo S 

PROVIDER: S-EPMC4167263 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature