The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation.

ABSTRACT:

Background

Recent advances have revealed a significant contribution of chemokines and their receptors in tumor growth, survival after chemotherapy, and organ-specific metastasis. The CXC chemokine receptor-7 (CXCR7) is the latest chemokine receptor implicated in cancer. Although over expressed in breast cancer cell lines and tumor tissues, its mechanism of action in breast cancer (BrCa) growth and metastasis is unclear. Studies in other cancers have implicated CXCR7 in cell proliferation, anti-apoptotic activity and cell-cell adhesion. The present study was initiated to examine the pattern of CXCR7 expression and its role in regulation of growth signaling in breast cancer.

Methods

The contribution of CXCR7 in BrCa cell proliferation was investigated in representative cell li

SUBMITTER: Salazar N 

PROVIDER: S-EPMC4167278 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature