Urine neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury after kidney surgery.

ABSTRACT:

Purpose

We evaluated urine NGAL as a marker of acute kidney injury in patients undergoing partial nephrectomy. We sought to identify the preoperative clinical features and surgical factors during partial nephrectomy that are associated with renal injury, as measured by increased urine NGAL vs controls.

Materials and methods

Using patients treated with radical nephrectomy or thoracic surgery as controls, we prospectively collected and analyzed urine and serum samples from patients treated with partial or radical nephrectomy, or thoracic surgery between April 2010 and April 2012. Urine was collected preoperatively and at multiple time points postoperatively. Differences in urine NGAL levels were analyzed among the 3 surgical groups using a generalized estimating equation model

SUBMITTER: Sprenkle PC 

PROVIDER: S-EPMC4167359 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature