Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells.

ABSTRACT: The prostate epithelial lineage hierarchy remains inadequately defined. Recent lineage-tracing studies have implied the existence of prostate luminal epithelial progenitors with extensive regenerative capacity. However, this capacity has not been demonstrated in prostate stem cell activity assays, probably owing to the strong susceptibility of luminal progenitors to anoikis. Here we show that constitutive expression of Notch1 intracellular domain impairs secretory function of mouse prostate luminal cells, suppresses anoikis of luminal epithelial cells by augmenting NF-κB activity independent of Hes1, stimulates luminal cell proliferation by potentiating PI3K-AKT signalling, and rescues the capacities of the putative prostate luminal progenitors for unipotent differentiation in vivo and sho

SUBMITTER: Kwon OJ 

PROVIDER: S-EPMC4167399 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature