Excess of proximal microsatellite-stable colorectal cancer in African Americans from a multiethnic study.

ABSTRACT:

Purpose

African Americans (AA) have the highest incidence of colorectal cancer compared with other U.S. populations and more proximal colorectal cancers. The objective is to elucidate the basis of these cancer disparities.

Experimental design

Of note, 566 AA and 328 non-Hispanic White (NHW) colorectal cancers were ascertained in five Chicago hospitals. Clinical and exposure data were collected. Microsatellite instability (MSI) and BRAF (V600E) and KRAS mutations were tested. Statistical significance of categorical variables was tested by the Fisher exact test or logistic regression and age by the Mann-Whitney U test.

Results

Over a 10-year period, the median age at diagnosis significantly decreased for both AAs (68-61; P < 0.01) and NHWs (64.5- 62; P = 0.04); more AA

SUBMITTER: Xicola RM 

PROVIDER: S-EPMC4167473 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature