Genetic substructure in cynomolgus macaques (Macaca fascicularis) on the island of Mauritius.

ABSTRACT:

Background

Nonhuman primates are commonly used in biomedical research as animal models of human disease and behavior. Compared to common rodent models, nonhuman primates are genetically, physiologically, behaviorally and neurologically more similar to humans owing to more recent shared ancestry and therefore provide the advantage of greater translational validity in preclinical studies. The cynomolgus macaque (Macaca fascicularis) is one of the most commonly used nonhuman primates in academic and industry settings, yet population genetic research has revealed significant substructure throughout the species distribution that may confound studies. Cynomolgus monkeys introduced to Mauritius specifically have previously been thought to maintain the least genetic heterogeneity of all cy

SUBMITTER: Ogawa LM 

PROVIDER: S-EPMC4167525 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature