Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.

ABSTRACT: Epithelial ovarian cancer is a highly heterogeneous disease and remains the most lethal gynaecological malignancy in the Western world. Therapeutic approaches need to account for inter-patient and intra-tumoural heterogeneity and detailed characterization of in vitro models representing the different histological and molecular ovarian cancer subtypes is critical to enable reliable preclinical testing. There are approximately 100 publicly available ovarian cancer cell lines but their cellular and molecular characteristics are largely undescribed. We have characterized 39 ovarian cancer cell lines under uniform conditions for growth characteristics, mRNA/microRNA expression, exon sequencing, drug response for clinically-relevant therapeutics and collated all available information on the orig

SUBMITTER: Beaufort CM 

PROVIDER: S-EPMC4167545 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature