Failure to identify HIV-infected individuals in a clinical trial using a single HIV rapid test for screening.

ABSTRACT:

Background

In the HIV Prevention Trials Network (HPTN) 061 study, 8 (2.3%) of 348 HIV-infected participants identified as HIV uninfected at study enrollment using a single HIV rapid test for screening were found to be HIV infected after additional testing.

Objectives

To evaluate the performance of different HIV assays for detection of HIV infection in HPTN 061 participants with missed infection and individuals with viral suppression.

Methods

Plasma samples from 8 HPTN 061 participants, 17 elite controllers, and 101 individuals on antiretroviral treatment (ART) were tested for HIV with 3 rapid tests, 2 laboratory-based immunoassays, and a Western blot assay. The HPTN 061 samples were also tested with 2 HIV RNA assays and an antiretroviral drug assay.

Results

Of

SUBMITTER: Piwowar-Manning E 

PROVIDER: S-EPMC4167641 | biostudies-literature | 2014 Mar-Apr

REPOSITORIES: biostudies-literature