The structure of an insect parvovirus (Galleria mellonella densovirus) at 3.7 A resolution.

ABSTRACT:

Background

Parvoviruses infect vertebrates, insects and crustaceans. Many arthropod parvoviruses (densoviruses) are highly pathogenic and kill approximately 90% of the host larvae within days, making them potentially effective as selective pesticides. Improved understanding of densoviral structure and function is therefore desirable. There are four different initiation sites for translation of the densovirus capsid protein mRNA, giving rise to the viral proteins VP1 to VP4. Sixty copies of the common, C-terminal domain make up the ordered part of the icosahedral capsid.

Results

The Galleria mellonella densovirus (GMDNV) capsid protein consists of a core beta-barrel motif, similar to that found in many other viral capsid proteins. The structure most closely resembles that of

SUBMITTER: Simpson AA 

PROVIDER: S-EPMC4167665 | biostudies-literature | 1998 Nov

REPOSITORIES: biostudies-literature