The association between statin medication and progression after surgery for localized renal cell carcinoma.

ABSTRACT:

Purpose

Evidence suggests that statins may influence pathways of renal cell carcinoma proliferation, although to our knowledge no study has examined the influence of statin medications on the progression of renal cell carcinoma in humans.

Materials and methods

We identified 2,608 patients with localized renal cell carcinoma who were treated surgically between 1995 and 2010 at our tertiary referral center. Competing risks Cox proportional hazards models were used to evaluate the relationship between statin use and time to local recurrence or progression (metastases or death from renal cell carcinoma) and overall survival. Statin use was modeled as a time dependent covariate as a sensitivity analysis. Models were adjusted for clinical and demographic features.

Results

O

SUBMITTER: Hamilton RJ 

PROVIDER: S-EPMC4167747 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature