Systematic review: identifying patients with chronic hepatitis C in need of early treatment and intensive monitoring--predictors and predictive models of disease progression.

ABSTRACT:

Background

Advances in hepatitis C therapies have led to increasing numbers of patients seeking treatment. As a result, logistical and financial concerns regarding how treatment can be provided to all patients with chronic hepatitis C (CHC) have emerged.

Aim

To evaluate predictors and predictive models of histological progression and clinical outcomes for patients with CHC.

Methods

MEDLINE via PubMed, EMBASE, Web of Science and Scopus were searched for studies published between January 2003 and June 2014. Two authors independently reviewed articles to select eligible studies and performed data abstraction.

Results

Twenty-nine studies representing 5817 patients from 20 unique cohorts were included. The outcome incidence rates were widely variable: 16-61% during

SUBMITTER: Konerman MA 

PROVIDER: S-EPMC4167918 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature