Focused ultrasound-mediated non-invasive brain stimulation: examination of sonication parameters.

ABSTRACT:

Background

Transcranial focused ultrasound (FUS) has emerged as a new brain stimulation modality. The range of sonication parameters for successful brain stimulation warrants further investigation.

Objective

The objective of this study was to examine the range of FUS sonication parameters that minimize the acoustic intensity/energy deposition while successfully stimulating the motor brain area in Sprague-Dawley rats.

Methods

We transcranially administered FUS to the somatomotor area of the rat brain and measured the acoustic intensity that caused excitatory effects with respect to different pulsing parameters (tone-burst duration, pulse-repetition frequency, duty cycle, and sonication duration) at 350 and 650 kHz of fundamental frequency.

Results

We observed th

SUBMITTER: Kim H 

PROVIDER: S-EPMC4167941 | biostudies-literature | 2014 Sep-Oct

REPOSITORIES: biostudies-literature