Association of promoter methylation of RUNX3 gene with the development of esophageal cancer: a meta analysis.

ABSTRACT:

Background

Runt-related transcription factor 3 (RUNX3) is a member of the runt-domain family of transcription factors. Emerging evidence indicates that RUNX3 is a tumor suppressor gene in several types of human cancers including esophageal cancer. However, the association between RUNX3 promoter methylation and esophageal cancer remains unclear. Here we conducted a systematic review and meta-analysis to quantitatively evaluate the effects of RUNX3 promoter methylation on the incidence of esophageal cancer.

Methods

A detailed literature search was made on Medline, Pubmed and Web of Science for related research publications written in English and/or Chinese. Methodological quality of the studies was also evaluated. The data were extracted and assessed by two reviewers independe

SUBMITTER: Wang Y 

PROVIDER: S-EPMC4167998 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature