Diffusion tensor imaging properties and neurobehavioral outcomes in children with hydrocephalus.

ABSTRACT:

Background and purpose

White matter structural alterations and the correlation with neuropsychological deficits in children with hydrocephalus have not been well investigated. In this prospective study, the objectives were the following: 1) to apply DTI to detect in vivo white matter alterations based on diffusion properties in children with acute hydrocephalus, 2) to quantify early neuropsychological deficits, and 3) to explore the correlation between potential neuropsychological deficits and abnormalities in functionally related white matter.

Materials and methods

A total of 44 children, 24 with hydrocephalus and 20 controls, were enrolled in the study. DTI indices, FA, MD, AD, and RD, were evaluated in the gCC, sCC, PLIC, and ALIC. The ABAS-II was used as a broad screener

SUBMITTER: Yuan W 

PROVIDER: S-EPMC4168017 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature