Comparative DNA damage and repair in echinoderm coelomocytes exposed to genotoxicants.

ABSTRACT: The capacity to withstand and repair DNA damage differs among species and plays a role in determining an organism's resistance to genotoxicity, life history, and susceptibility to disease. Environmental stressors that affect organisms at the genetic level are of particular concern in ecotoxicology due to the potential for chronic effects and trans-generational impacts on populations. Echinoderms are valuable organisms to study the relationship between DNA repair and resistance to genotoxic stress due to their history and use as ecotoxicological models, little evidence of senescence, and few reported cases of neoplasia. Coelomocytes (immune cells) have been proposed to serve as sensitive bioindicators of environmental stress and are often used to assess genotoxicity; however, little is know

SUBMITTER: El-Bibany AH 

PROVIDER: S-EPMC4168213 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature