Discovering regulatory motifs in the Plasmodium genome using comparative genomics.

ABSTRACT:

Motivation

Understanding gene regulation in Plasmodium, the causative agent of malaria, is an important step in deciphering its complex life cycle as well as leading to possible new targets for therapeutic applications. Very little is known about gene regulation in Plasmodium, and in particular, few regulatory elements have been identified. Such discovery has been significantly hampered by the high A-T content of some of the genomes of Plasmodium species, as well as the challenge in associating discovered regulatory elements to gene regulatory cascades due to Plasmodium's complex life cycle.

Results

We report a new method of using comparative genomics to systematically discover motifs in Plasmodium without requiring any functional data. Different from previous methods, our m

SUBMITTER: Wu J 

PROVIDER: S-EPMC4168299 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature