Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum antigens.

ABSTRACT:

Background

Tools that estimate recent and long-term malaria transmission in a population would be highly useful for malaria elimination programs.

Methods

The prevalence of antibodies to 11 Plasmodium falciparum antigens was assessed by cytometric bead assay or enzyme-linked immunosorbent assay in 1000 people in a highland area of Kenya over 14 months, during a period of interrupted malaria transmission.

Results

Antibodies differed by antigen in acquisition with age: rapid (>80% antibody positive by age 20 years, 5 antigens), moderate (>40% positive by age 20 years, 3 antigens), or slow (<40% positive by age 20 years, 3 antigens). Antibody seroreversion rates in the 14 months between samples decreased with age rapidly (7 antigens), slowly (3 antigens), or remained high

SUBMITTER: Ondigo BN 

PROVIDER: S-EPMC4168304 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature