Characterizing variability in warfarin dose requirements in children using modelling and simulation.

ABSTRACT:

Aims

Although genetic, clinical and demographic factors have been shown to explain approximately half of the inter-individual variability in warfarin dose requirement in adults, less is known about causes of dose variability in children. This study aimed to identify and quantify major genetic, clinical and demographic sources of warfarin dose variability in children using modelling and simulation.

Methods

Clinical, demographic and genetic data from 163 children with a median age of 6.3 years (range 0.06-18.9 years), covering over 183 years of warfarin therapy and 6445 INR observations were used to update and optimize a published adult pharmacometric warfarin model for use in children.

Results

Genotype effects in children were found to be comparable with what has been

SUBMITTER: Hamberg AK 

PROVIDER: S-EPMC4168390 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature