Correlation of the electrophysiological profiles and sodium channel transcripts of individual rat dorsal root ganglia neurons.

ABSTRACT: Voltage gated sodium channels (Nav channels) play an important role in nociceptive transmission. They are intimately tied to the genesis and transmission of neuronal firing. Five different isoforms (Nav1.3, Nav1.6, Nav1.7, Nav1.8, and Nav1.9) have been linked to nociceptive responses. A change in the biophysical properties of these channels or in their expression levels occurs in different pathological pain states. However, the precise involvement of the isoforms in the genesis and transmission of nociceptive responses is unknown. The aim of the present study was to investigate the synergy between the different populations of Nav channels that give individual neurons a unique electrophysical profile. We used the patch-clamp technique in the whole-cell configuration to record Nav currents a

SUBMITTER: Theriault O 

PROVIDER: S-EPMC4168718 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature