Oxazinin A, a pseudodimeric natural product of mixed biosynthetic origin from a filamentous fungus.

ABSTRACT: A racemic, prenylated polyketide dimer, oxazinin A (1), was isolated from a novel filamentous fungus in the class Eurotiomycetes, and its structure was elucidated spectroscopically. The pentacyclic structure of oxazinin A (1) is a unique combination of benzoxazine, isoquinoline, and a pyran ring. Oxazinin A (1) exhibited antimycobacterial activity and modestly antagonized transient receptor potential (TRP) channels.

SUBMITTER: Lin Z 

PROVIDER: S-EPMC4168773 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature