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P(O)R2-directed Pd-catalyzed C-H functionalization of biaryl derivatives to synthesize chiral phosphorous ligands.

ABSTRACT: Chiral phosphorus ligands have been widely used in transition metal-catalyzed asymmetric reactions. Herein, we report a new synthesis approach of chiral biaryls containing a phosphorus moiety using P(O)R2-directed Pd-catalyzed C-H activation; the functionalized products are produced with good enantioselectivity.

SUBMITTER: Hu RB

PROVIDER: S-EPMC4168959 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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P(O)R2-directed Pd-catalyzed C-H functionalization of biaryl derivatives to synthesize chiral phosphorous ligands.

Hu Rong-Bin RB Wang Hong-Li HL Zhang Hong-Yu HY Zhang Heng H Ma Yan-Na YN Yang Shang-Dong SD

Beilstein journal of organic chemistry 20140902

Chiral phosphorus ligands have been widely used in transition metal-catalyzed asymmetric reactions. Herein, we report a new synthesis approach of chiral biaryls containing a phosphorus moiety using P(O)R2-directed Pd-catalyzed C-H activation; the functionalized products are produced with good enantioselectivity. ...[more]

PMID: 25246966

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