Fine-mapping and selective sweep analysis of QTL for cold tolerance in Drosophila melanogaster.

ABSTRACT: There is a growing interest in investigating the relationship between genes with signatures of natural selection and genes identified in QTL mapping studies using combined population and quantitative genetics approaches. We dissected an X-linked interval of 6.2 Mb, which contains two QTL underlying variation in chill coma recovery time (CCRT) in Drosophila melanogaster from temperate (European) and tropical (African) regions. This resulted in two relatively small regions of 131 kb and 124 kb. The latter one co-localizes with a very strong selective sweep in the European population. We examined the genes within and near the sweep region individually using gene expression analysis and P-element insertion lines. Of the genes overlapping with the sweep, none appears to be related to CCRT. Howe

SUBMITTER: Wilches R 

PROVIDER: S-EPMC4169155 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature