Total synthesis of Δ¹²-prostaglandin J₃, a highly potent and selective antileukemic agent.

ABSTRACT: A catalytic asymmetric total synthesis of the potent and selective antileukemic Δ(12)-prostaglandin J3 (Δ(12)-PGJ3) is described. The convergent synthesis proceeded through intermediates 2 and 3, formed enantioselectively from readily available starting materials and coupled through an aldol reaction followed by dehydration to afford stereoselectively the cyclopentenone alkylidene structural motif of the molecule.

SUBMITTER: Nicolaou KC 

PROVIDER: S-EPMC4169176 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature