The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition.

ABSTRACT: A heterogeneous population of inhibitory neurons controls the flow of information through a neural circuit. Inhibitory synapses that form on pyramidal neuron dendrites modulate the summation of excitatory synaptic potentials and prevent the generation of dendritic calcium spikes. Precisely timed somatic inhibition limits both the number of action potentials and the time window during which firing can occur. The activity-dependent transcription factor NPAS4 regulates inhibitory synapse number and function in cell culture, but how this transcription factor affects the inhibitory inputs that form on distinct domains of a neuron in vivo was unclear. Here we show that in the mouse hippocampus behaviourally driven expression of NPAS4 coordinates the redistribution of inhibitory synapses made ont

SUBMITTER: Bloodgood BL 

PROVIDER: S-EPMC4169177 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature