Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture.

ABSTRACT:

Background

Osteoporotic fracture (OF) as a clinical endpoint is a major complication of osteoporosis. To screen for OF susceptibility genes, we performed a genome-wide association study and carried out de novo replication analysis of an East Asian population.

Methods

Association was tested using a logistic regression analysis. A meta-analysis was performed on the combined results using effect size and standard errors estimated for each study.

Results

In a combined meta-analysis of a discovery cohort (288 cases and 1139 controls), three hospital based sets in replication stage I (462 cases and 1745 controls), and an independent ethnic group in replication stage II (369 cases and 560 for controls), we identified a new locus associated with OF (rs784288 in the MECOM gene

SUBMITTER: Hwang JY 

PROVIDER: S-EPMC4169276 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature