Association between age at antiretroviral therapy initiation and 24-month immune response in West-African HIV-infected children.

ABSTRACT:

Objective

We describe the association between age at antiretroviral therapy (ART) initiation and 24-month CD4 cell response in West African HIV-infected children.

Methods

All HIV-infected children from the IeDEA paediatric West African cohort, initiating ART, with at least two CD4 cell count measurements, including one at ART initiation (baseline) were included. CD4 cell gain on ART was estimated using a multivariable linear mixed model adjusted for baseline variables: age, CD4 cell count, sex, first-line ART regimen. Kaplan-Meier survival curves and a Cox proportional hazards regression model compared immune recovery for age within 24 months post-ART.

Results

Of the 4808 children initiated on ART, 3014 were enrolled at a median age of 5.6 years; 61.2% were immunodefi

SUBMITTER: Desmonde S 

PROVIDER: S-EPMC4169343 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature