Testosterone and dihydrotestosterone and incident ischaemic stroke in men in the Cardiovascular Health Study.

ABSTRACT:

Objective

Ischaemic stroke is a major cause of morbidity and mortality in elderly men. Our main objective was to examine whether testosterone (T) or dihydrotestosterone (DHT) was associated with incident ischaemic stroke in elderly men.

Design

Cohort study.

Participants

Elderly men in the Cardiovascular Health Study who had no history of stroke, heart disease or prostate cancer as of 1994 and were followed until December 2010.

Measurements

Adjudicated ischaemic stroke.

Results

Among 1032 men (mean age 76, range 66-97), followed for a median of 10 years, 114 had an incident ischaemic stroke. Total T and free T were not significantly associated with stroke risk, while DHT had a nonlinear association with incident stroke (P = 0·006) in analyses adjusted for

SUBMITTER: Shores MM 

PROVIDER: S-EPMC4169352 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature