Integrative model of the immune response to a pulmonary macrophage infection: what determines the infection duration?

ABSTRACT: The immune mechanisms which determine the infection duration induced by pathogens targeting pulmonary macrophages are poorly known. To explore the impact of such pathogens, it is indispensable to integrate the various immune mechanisms and to take into account the variability in pathogen virulence and host susceptibility. In this context, mathematical models complement experimentation and are powerful tools to represent and explore the complex mechanisms involved in the infection and immune dynamics. We developed an original mathematical model in which we detailed the interactions between the macrophages and the pathogen, the orientation of the adaptive response and the cytokine regulations. We applied our model to the Porcine Respiratory and Reproductive Syndrome virus (PRRSv), a major co

SUBMITTER: Go N 

PROVIDER: S-EPMC4169448 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature