The effects of vaccination and immunity on bacterial infection dynamics in vivo.

ABSTRACT: Salmonella enterica infections are a significant global health issue, and development of vaccines against these bacteria requires an improved understanding of how vaccination affects the growth and spread of the bacteria within the host. We have combined in vivo tracking of molecularly tagged bacterial subpopulations with mathematical modelling to gain a novel insight into how different classes of vaccines and branches of the immune response protect against secondary Salmonella enterica infections of the mouse. We have found that a live Salmonella vaccine significantly reduced bacteraemia during a secondary challenge and restrained inter-organ spread of the bacteria in the systemic organs. Further, fitting mechanistic models to the data indicated that live vaccine immunisation enhanced bot

SUBMITTER: Coward C 

PROVIDER: S-EPMC4169467 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature