No beneficial effect of general and specific anti-inflammatory therapies on aortic dilatation in Marfan mice.

ABSTRACT:

Aims

Patients with Marfan syndrome have an increased risk of life-threatening aortic complications, mostly preceded by aortic dilatation. In the FBN1(C1039G/+) Marfan mouse model, losartan decreases aortic root dilatation. We recently confirmed this beneficial effect of losartan in adult patients with Marfan syndrome. The straightforward translation of this mouse model to man is reassuring to test novel treatment strategies. A number of studies have shown signs of inflammation in aortic tissue of Marfan patients. This study examined the efficacy of anti-inflammatory therapies in attenuating aortic root dilation in Marfan syndrome and compared effects to the main preventative agent, losartan.

Methods and results

To inhibit inflammation in FBN1(C1039G/+) Marfan mice, we treate

SUBMITTER: Franken R 

PROVIDER: S-EPMC4169510 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature