Heterogeneity in the inter-tumor transcriptome of high risk prostate cancer.

ABSTRACT:

Background

Genomic analyses of hundreds of prostate tumors have defined a diverse landscape of mutations and genome rearrangements, but the transcriptomic effect of this complexity is less well understood, particularly at the individual tumor level. We selected a cohort of 25 high-risk prostate tumors, representing the lethal phenotype, and applied deep RNA-sequencing and matched whole genome sequencing, followed by detailed molecular characterization.

Results

Ten tumors were exposed to neo-adjuvant hormone therapy and expressed marked evidence of therapy response in all except one extreme case, which demonstrated early resistance via apparent neuroendocrine transdifferentiation. We observe high inter-tumor heterogeneity, including unique sets of outlier transcripts in each

SUBMITTER: Wyatt AW 

PROVIDER: S-EPMC4169643 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature