A new ibuprofen derivative inhibits platelet aggregation and ROS mediated platelet apoptosis.

ABSTRACT: Thrombocytopenia is a serious issue connected with the pathogenesis of several human diseases including chronic inflammation, arthritis, Alzheimer's disease, cardiovascular diseases (CVDs) and other oxidative stress-associated pathologies. The indiscriminate use of antibiotics and other biological drugs are reported to result in thrombocytopenia, which is often neglected during the treatment regime. In addition, augmented oxidative stress induced by drugs and pathological conditions has also been shown to induce thrombocytopenia, which seems to be the most obvious consequence of elevated rate of platelet apoptosis. Thus, blocking oxidative stress-induced platelet apoptosis would be of prime importance in order to negotiate thrombocytopenia and associated human pathologies. The current stud

SUBMITTER: Rakesh KS 

PROVIDER: S-EPMC4169656 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature