Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis.

ABSTRACT:

Background

Treatment strategies blocking tumour necrosis factor (anti-TNF) have proven very successful in patients with rheumatoid arthritis (RA). However, a significant subset of patients does not respond for unknown reasons. Currently, there are no means of identifying these patients before treatment. This study was aimed at identifying genetic factors predicting anti-TNF treatment outcome in patients with RA using a genome-wide association approach.

Methods

We conducted a multistage, genome-wide association study with a primary analysis of 2 557 253 single-nucleotide polymorphisms (SNPs) in 882 patients with RA receiving anti-TNF therapy included through the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry and the database of Apotheekzorg. Linear regression analysis

SUBMITTER: Umicevic Mirkov M 

PROVIDER: S-EPMC4169706 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature