Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity.

ABSTRACT: Ras-driven cancer cells upregulate basal autophagy that degrades and recycles intracellular proteins and organelles. Autophagy-mediated proteome degradation provides free amino acids to support metabolism and macromolecular synthesis, which confers a survival advantage in starvation and promotes tumorigenesis. While the degradation of isolated protein substrates by autophagy has been implicated in controlling cellular function, the extent and specificity by which autophagy remodels the cellular proteome and the underlying functional consequences were unknown. Here we compared the global proteome of autophagy-functional and -deficient Ras-driven cancer cells, finding that autophagy affects the majority of the proteome yet is highly selective. While levels of vesicle trafficking proteins imp

SUBMITTER: Mathew R 

PROVIDER: S-EPMC4169768 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature