Circulation of Coxsackievirus A6 in hand-foot-mouth disease in Guangzhou, 2010-2012.

ABSTRACT:

Background

Hand, foot and mouth disease (HFMD) is usually caused by Enterovirus 71(EV71), and Coxsackievirus A16 (CV-A16) in Guangzhou, the biggest city of South China. However, Coxsackievirus A6 (CV-A6) were observed increased dramatically from 2010-2012.

Methods

In order to understand and to describe the epidemiologic and genetic characteristics of CV-A6, specimens of 5482 suspected HFMD cases were collected and examined by real-time fluorescence PCR. All samples positive for enteroviruses were analyzed by descriptive statistics. Phylogenetic analysis of CV-A6 based on the VP1 sequences was performed to investigate molecular and evolutionary characteristics.

Results

Coxsackievirus A6 increased dramatically from 9.04% in 2010 to 23.21% in 2012 and became one of the m

SUBMITTER: Di B 

PROVIDER: S-EPMC4169826 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature