Controlled study of 50-Hz repetitive transcranial magnetic stimulation for the treatment of Parkinson disease.

ABSTRACT:

Objective

To investigate the safety and efficacy of 50-Hz repetitive transcranial magnetic stimulation (rTMS) in the treatment of motor symptoms in Parkinson disease (PD).

Background

Progression of PD is characterized by the emergence of motor deficits that gradually respond less to dopaminergic therapy. rTMS has shown promising results in improving gait, a major cause of disability, and may provide a therapeutic alternative. Prior controlled studies suggest that an increase in stimulation frequency might enhance therapeutic efficacy.

Methods

In this randomized, double blind, sham-controlled study, the authors investigated the safety and efficacy of 50-Hz rTMS of the motor cortices in 8 sessions over 2 weeks. Assessment of safety and clinical efficacy over a 1-month p

SUBMITTER: Benninger DH 

PROVIDER: S-EPMC4169897 | biostudies-literature | 2012 Nov-Dec

REPOSITORIES: biostudies-literature