Voltage-sensitive dye imaging of transcranial magnetic stimulation-induced intracortical dynamics.

ABSTRACT: Transcranial magnetic stimulation (TMS) is widely used in clinical interventions and basic neuroscience. Additionally, it has become a powerful tool to drive plastic changes in neuronal networks. However, highly resolved recordings of the immediate TMS effects have remained scarce, because existing recording techniques are limited in spatial or temporal resolution or are interfered with by the strong TMS-induced electric field. To circumvent these constraints, we performed optical imaging with voltage-sensitive dye (VSD) in an animal experimental setting using anaesthetized cats. The dye signals reflect gradual changes in the cells' membrane potential across several square millimeters of cortical tissue, thus enabling direct visualization of TMS-induced neuronal population dynamics. After

SUBMITTER: Kozyrev V 

PROVIDER: S-EPMC4169942 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature