Primed 3D injectable microniches enabling low-dosage cell therapy for critical limb ischemia.

ABSTRACT: The promise of cell therapy for repair and restoration of damaged tissues or organs relies on administration of large dose of cells whose healing benefits are still limited and sometimes irreproducible due to uncontrollable cell loss and death at lesion sites. Using a large amount of therapeutic cells increases the costs for cell processing and the risks of side effects. Optimal cell delivery strategies are therefore in urgent need to enhance the specificity, efficacy, and reproducibility of cell therapy leading to minimized cell dosage and side effects. Here, we addressed this unmet need by developing injectable 3D microscale cellular niches (microniches) based on biodegradable gelatin microcryogels (GMs). The microniches are constituted by in vitro priming human adipose-derived mesenchym

SUBMITTER: Li Y 

PROVIDER: S-EPMC4169950 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature