Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes.

ABSTRACT: Delineating the molecular basis of individual differences in the stress response is critical to understanding the pathophysiology and treatment of posttraumatic stress disorder (PTSD). In this study, 7 d after predator-scent-stress (PSS) exposure, male and female rats were classified into vulnerable (i.e., "PTSD-like") and resilient (i.e., minimally affected) phenotypes on the basis of their performance on a variety of behavioral measures. Genome-wide expression profiling in blood and two limbic brain regions (amygdala and hippocampus), followed by quantitative PCR validation, was performed in these two groups of animals, as well as in an unexposed control group. Differentially expressed genes were identified in blood and brain associated with PSS-exposure and with distinct behavioral prof

SUBMITTER: Daskalakis NP 

PROVIDER: S-EPMC4169965 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature