Nup98 promotes antiviral gene expression to restrict RNA viral infection in Drosophila.

ABSTRACT: In response to infection, the innate immune system rapidly activates an elaborate and tightly orchestrated gene expression program to induce critical antimicrobial genes. While many key players in this program have been identified in disparate biological systems, it is clear that there are additional uncharacterized mechanisms at play. Our previous studies revealed that a rapidly-induced antiviral gene expression program is active against disparate human arthropod-borne viruses in Drosophila. Moreover, one-half of this program is regulated at the level of transcriptional pausing. Here we found that Nup98, a virus-induced gene, was antiviral against a panel of viruses both in cells and adult flies since its depletion significantly enhanced viral infection. Mechanistically, we found that Nup

SUBMITTER: Panda D 

PROVIDER: S-EPMC4169978 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature