Role of the tumor suppressor IQGAP2 in metabolic homeostasis: Possible link between diabetes and cancer.

ABSTRACT: Deficiency of IQGAP2, a scaffolding protein expressed primarily in liver leads to rearrangements of hepatic protein compartmentalization and altered regulation of enzyme functions predisposing development of hepatocellular carcinoma and diabetes. Employing a systems approach with proteomics, metabolomics and fluxes characterizations, we examined the effects of IQGAP2 deficient proteomic changes on cellular metabolism and the overall metabolic phenotype. Iqgap2^-/- mice demonstrated metabolic inflexibility, fasting hyperglycemia and obesity. Such phenotypic characteristics were associated with aberrant hepatic regulations of glycolysis/gluconeogenesis, glycogenolysis, lipid homeostasis and futile cycling corroborated with corresponding proteomic changes in cytosolic and mit

SUBMITTER: Vaitheesvaran B 

PROVIDER: S-EPMC4169985 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature