1-stearoylglycerol is associated with risk of prostate cancer: results from serum metabolomic profiling.

ABSTRACT: Although prostate cancer is the most commonly diagnosed cancer among men in developed populations, recent recommendations against routine prostate-specific antigen screening have cast doubt on its utility for early detection. We compared the metabolomic profiles of prospectively collected fasting serum from 74 prostate cancer cases and 74 controls selected from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of male smokers. Circulating 1-stearoylglycerol (1-SG, or 1-monostearin) was statistically significantly inversely associated with risk of prostate cancer after Bonferroni correction for multiple comparisons (i.e., 420 identified metabolites) (OR=0.34, 95% CI=0.20 - 0.58, p=6.3 × 10^-5). The magnitude of this association did not differ by disease aggressive

SUBMITTER: Mondul AM 

PROVIDER: S-EPMC4169990 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature