The relationship between insulin resistance and vascular calcification in coronary arteries, and the thoracic and abdominal aorta: the Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Objective

Insulin resistance may be related to vascular calcification as both are associated with abdominal obesity. We investigated the association of insulin resistance with abdominal aortic calcium (AAC), coronary artery calcium (CAC) and thoracic aortic calcium (TAC), and whether it differs according to different levels of subcutaneous fat area (SFA) and visceral fat area (VFA) in a cross-sectional study design.

Methods

We investigated 1632 participants without diabetes from the Multi-Ethnic Study of Atherosclerosis with valid data on homeostasis model assessment index (HOMA-IR), AAC, CAC, and TAC. Adipocytokines, SFA, and VFA were also determined.

Results

HOMA-IR was associated with the presence of CAC, but not AAC and TAC, and the association remained significan

SUBMITTER: Ong KL 

PROVIDER: S-EPMC4170001 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature