Interaction between cigarette smoking and hepatitis B and C virus infection on the risk of liver cancer: a meta-analysis.

ABSTRACT:

Introduction

Chronic infection with hepatitis B (HBV) and C viruses (HCV) as well as cigarette smoking are established risk factors of hepatocellular carcinoma (HCC), but it is unclear whether an interaction exists between these factors in causing hepatocellular carcinogenesis. We conducted a meta-analysis to evaluate the interaction of HBV and HCV infection and cigarette smoking on the risk of HCC.

Methods

We systematically searched the PUBMED and the China National Knowledge Infrastructure databases. A total of 16 eligible publications were identified. Cigarette smoking and chronic HBV and HCV infections were dichotomized into present or absent. Additive (S) and multiplicative interaction indexes (V) between smoking and each of the two infections and their 95% confidence i

SUBMITTER: Chuang SC 

PROVIDER: S-EPMC4170071 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature