The Look AHEAD Trial: bone loss at 4-year follow-up in type 2 diabetes.

ABSTRACT:

Objective

To determine whether an intensive lifestyle intervention (ILI) designed to sustain weight loss and improve physical fitness in overweight or obese persons with type 2 diabetes was associated with bone loss after 4 years of follow-up.

Research design and methods

This randomized controlled trial of intensive weight loss compared an ILI with a diabetes support and education (DSE) group among 1,309 overweight or obese subjects. Bone mineral density was assessed at baseline and after 1 year and 4 years of intervention.

Results

ILI was effective in producing significant weight loss (5.3% vs. 1.8% in ILI and DSE, respectively; P < 0.01) and increased fitness (6.4% vs. -0.8%) at year 4. In men, ILI participants had a greater rate of bone loss during the first year (

SUBMITTER: Lipkin EW 

PROVIDER: S-EPMC4170123 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature