Effects of weight loss, weight cycling, and weight loss maintenance on diabetes incidence and change in cardiometabolic traits in the Diabetes Prevention Program.

ABSTRACT:

Objective

This study examined specific measures of weight loss in relation to incident diabetes and improvement in cardiometabolic risk factors.

Research design and methods

This prospective, observational study analyzed nine weight measures, characterizing baseline weight, short- versus long-term weight loss, short- versus long-term weight regain, and weight cycling, within the Diabetes Prevention Program (DPP) lifestyle intervention arm (n = 1,000) for predictors of incident diabetes and improvement in cardiometabolic risk factors over 2 years.

Results

Although weight loss in the first 6 months was protective of diabetes (hazard ratio [HR] 0.94 per kg, 95% CI 0.90, 0.98; P < 0.01) and cardiometabolic risk factors (P < 0.01), weight loss from 0 to 2 years was the stro

SUBMITTER: Delahanty LM 

PROVIDER: S-EPMC4170126 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature