Elevated pretransplantation soluble BAFF is associated with an increased risk of acute antibody-mediated rejection.

ABSTRACT:

Background

B cells play an important role in renal allograft pathology, particularly in acute and chronic antibody-mediated rejection (AMR). B-cell activating factor belonging to the tumor necrosis factor family (BAFF; also known as BLyS) is a cytokine that enhances B-cell survival and proliferation.

Methods

We analyzed serum BAFF levels in 32 patients undergoing antibody-incompatible (Ai) renal transplantation and 319 antibody-compatible transplant recipients and sought to determine whether there was a correlation with acute rejection and with transplant function and survival.

Results

We demonstrate that, in patients undergoing Ai transplantation, elevated serum BAFF levels at baseline (before both antibody removal/desensitization and transplantation) are associated

SUBMITTER: Banham G 

PROVIDER: S-EPMC4170143 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature